​We offer service and support for customers around the globe and provide state-of-the-art know-how.
Interdisciplinary teamwork is combined in a unique way with the latest technologies. Chemistry, microbiology, molecular biology, and nanotechnology are networked together. All their specific techniques, equipment and systems are located in a single place, thus enabling a privileged combination of focus and openness that makes us fast, flexible, and cost-effective.
Selection of services
For detailed lists of services please click on the topics left.
Ames-Test according to OECD 471
This bacterial reverse mutation test, also entitled by its developer Bruce Ames, uses amino acid depending strains of Salmonella typhimurium and Escherichia coli to detect mutagen potentials of chemical substances.
The test can provide useful information on the types of mutations induced by genotoxic agents. It has been standardized by the OECD 471 guideline.
The new ICH M7 guideline guideline (Assessment and Control of DNA Reactive (Mutagenic) Impurities in Pharmaceuticals) instructs with immediate effect the use of the Ames test for:
a) All new developed API (Active Pharmaceutical Ingredients)
b) API which are on the market, but with any change in the production process
c) Every single component of product combinations and impurities
Omya Microbiology provides a fast, inexpensive and sure realization of the Ames Test, especially also for substances of low solubility.
Aqua toxicity studies according to OECD 201
This test evaluates the aqua toxic potential of industrial chemicals and can be used to determine the EC 50 value that is a necessary statement in MSDS (Material Safety Data Sheets) documents of chemicals.
In addition to pure chemicals, Omya Microbiology can analyse the impact of industrial processes (e.g. flotation) on modifications, synergisms, mitigation or enhancement for the aqua toxic potential. Therefore, standardized assays according to the newest release of the OECD 201 guideline as well as customized studies are available.
Example study from Omya of the OECD 201 "Freshwater Alga and Cyanobacteria Growth Inhibition Test"
Bacterial and Fungal Identification by Bruker MALDI-TOF MS Microflex
A rapid, cost-efficient and reliable method for the identification of microorganisms on the basis of molecular fingerprints. Characteristic patterns of highly abundant proteins are used to accurately identify a particular microorganism. By matching the respective pattern with an extensive open database it is possible to determine the identity of the microorganism down to the species level.
Example MALDI-TOF analysis
MLST -Multi Locus Sequence Typing
As initial step, MALDI-TOF-MS offers fast, cheap and in depth analysis of bacterial strains. It is superior over classical 16S rRNA sequencing in price, speed and accuracy. The MLST (Multi Locus Sequence Typing) is a rapid and reliable way to characterize bacteria further (e.g. Salmonella) on species and strain level reporting even the serotype. It overcomes 16s rRNA sequencing ambiguities by simultaneous determination of 7 characteristic genes. It is faster than coagulation based serotyping especially for rare serotypes.
MALDI TOF MS compared to MLST
For more information please contact us:
info.microbiology@omya.com
+41 62 789 2415 or
+41 62 789 2512
